diff --git a/sanic/http.py b/sanic/http.py
index 8aaa4aa0..b71f1a74 100644
--- a/sanic/http.py
+++ b/sanic/http.py
@@ -226,7 +226,9 @@ class Http:
             data = b""
             self.response_func = self.head_response_ignored
         headers["connection"] = "keep-alive" if self.keep_alive else "close"
-        ret = format_http1_response(status, res.processed_headers) + data
+        ret = format_http1_response(status, res.processed_headers)
+        if data:
+            ret += data
         # Send a 100-continue if expected and not Expectation Failed
         if self.expecting_continue:
             self.expecting_continue = False
diff --git a/sanic/response.py b/sanic/response.py
index fc0866f8..bc6c3aa0 100644
--- a/sanic/response.py
+++ b/sanic/response.py
@@ -54,6 +54,8 @@ class BaseHTTPResponse:
         """
         if data is None and end_stream is None:
             end_stream = True
+        if end_stream and not data and self.stream.send is None:
+            return
         data = data.encode() if hasattr(data, "encode") else data or b""
         await self.stream.send(data, end_stream=end_stream)
 
diff --git a/tests/test_request_stream.py b/tests/test_request_stream.py
index f00f3253..f9c346ce 100644
--- a/tests/test_request_stream.py
+++ b/tests/test_request_stream.py
@@ -1,5 +1,11 @@
+import asyncio
+
+from contextlib import closing
+from socket import socket
+
 import pytest
 
+from sanic import Sanic
 from sanic.blueprints import Blueprint
 from sanic.exceptions import HeaderExpectationFailed
 from sanic.response import json, stream, text
@@ -582,5 +588,84 @@ def test_streaming_new_api(app):
     assert response.status == 200
     res = response.json
     assert isinstance(res, list)
-    assert len(res) > 1
     assert "".join(res) == data
+
+def test_streaming_echo():
+    """2-way streaming chat between server and client."""
+    app = Sanic(name=__name__)
+
+    @app.post("/echo", stream=True)
+    async def handler(request):
+        res = await request.respond(content_type="text/plain; charset=utf-8")
+        # Send headers
+        await res.send(end_stream=False)
+        # Echo back data (case swapped)
+        async for data in request.stream:
+            await res.send(data.swapcase())
+        # Add EOF marker after successful operation
+        await res.send(b"-", end_stream=True)
+
+    @app.listener("after_server_start")
+    async def client_task(app, loop):
+        try:
+            reader, writer = await asyncio.open_connection(*addr)
+            await client(app, reader, writer)
+        finally:
+            writer.close()
+            app.stop()
+
+    async def client(app, reader, writer):
+        # Unfortunately httpx does not support 2-way streaming, so do it by hand.
+        host = f"host: {addr[0]}:{addr[1]}\r\n".encode()
+        writer.write(
+            b"POST /echo HTTP/1.1\r\n" + host + b"content-length: 2\r\n"
+            b"content-type: text/plain; charset=utf-8\r\n"
+            b"\r\n"
+        )
+        # Read response
+        res = b""
+        while not b"\r\n\r\n" in res:
+            res += await reader.read(4096)
+        assert res.startswith(b"HTTP/1.1 200 OK\r\n")
+        assert res.endswith(b"\r\n\r\n")
+        buffer = b""
+
+        async def read_chunk():
+            nonlocal buffer
+            while not b"\r\n" in buffer:
+                data = await reader.read(4096)
+                assert data
+                buffer += data
+            size, buffer = buffer.split(b"\r\n", 1)
+            size = int(size, 16)
+            if size == 0:
+                return None
+            while len(buffer) < size + 2:
+                data = await reader.read(4096)
+                assert data
+                buffer += data
+                print(res)
+            assert buffer[size : size + 2] == b"\r\n"
+            ret, buffer = buffer[:size], buffer[size + 2 :]
+            return ret
+
+        # Chat with server
+        writer.write(b"a")
+        res = await read_chunk()
+        assert res == b"A"
+
+        writer.write(b"b")
+        res = await read_chunk()
+        assert res == b"B"
+
+        res = await read_chunk()
+        assert res == b"-"
+
+        res = await read_chunk()
+        assert res == None
+
+    # Use random port for tests
+    with closing(socket()) as sock:
+        sock.bind(("127.0.0.1", 0))
+        addr = sock.getsockname()
+        app.run(sock=sock, access_log=False)