diff --git a/sanic/app.py b/sanic/app.py
index 1704aa67..5d1e5547 100644
--- a/sanic/app.py
+++ b/sanic/app.py
@@ -206,7 +206,7 @@ class Sanic(BaseSanic, metaclass=TouchUpMeta):
         if self.config.REGISTER:
             self.__class__.register_app(self)
 
-        if self.config.USE_UVLOOP:
+        if not self.config.NO_UVLOOP:
             use_uvloop()
 
         self.router.ctx.app = self
diff --git a/sanic/config.py b/sanic/config.py
index 3a7c280a..310a289b 100644
--- a/sanic/config.py
+++ b/sanic/config.py
@@ -27,6 +27,7 @@ DEFAULT_CONFIG = {
     "GRACEFUL_SHUTDOWN_TIMEOUT": 15.0,  # 15 sec
     "KEEP_ALIVE_TIMEOUT": 5,  # 5 seconds
     "KEEP_ALIVE": True,
+    "NO_UVLOOP": False,
     "PROXIES_COUNT": None,
     "REAL_IP_HEADER": None,
     "REGISTER": True,
@@ -36,7 +37,6 @@ DEFAULT_CONFIG = {
     "REQUEST_MAX_SIZE": 100000000,  # 100 megabytes
     "REQUEST_TIMEOUT": 60,  # 60 seconds
     "RESPONSE_TIMEOUT": 60,  # 60 seconds
-    "USE_UVLOOP": True,
     "WEBSOCKET_MAX_SIZE": 2 ** 20,  # 1 megabyte
     "WEBSOCKET_PING_INTERVAL": 20,
     "WEBSOCKET_PING_TIMEOUT": 20,
@@ -52,6 +52,7 @@ class Config(dict):
     GRACEFUL_SHUTDOWN_TIMEOUT: float
     KEEP_ALIVE_TIMEOUT: int
     KEEP_ALIVE: bool
+    NO_UVLOOP: bool
     PROXIES_COUNT: Optional[int]
     REAL_IP_HEADER: Optional[str]
     REGISTER: bool
@@ -62,7 +63,6 @@ class Config(dict):
     REQUEST_TIMEOUT: int
     RESPONSE_TIMEOUT: int
     SERVER_NAME: str
-    USE_UVLOOP: bool
     WEBSOCKET_MAX_SIZE: int
     WEBSOCKET_PING_INTERVAL: int
     WEBSOCKET_PING_TIMEOUT: int