diff --git a/examples/vhosts.py b/examples/vhosts.py
new file mode 100644
index 00000000..50e85494
--- /dev/null
+++ b/examples/vhosts.py
@@ -0,0 +1,18 @@
+from sanic.response import text
+from sanic import Sanic
+
+# Usage
+# curl -H "Host: example.com" localhost:8000
+# curl -H "Host: sub.example.com" localhost:8000
+
+app = Sanic()
+
+@app.route('/', host="example.com")
+async def hello(request):
+    return text("Answer")
+@app.route('/', host="sub.example.com")
+async def hello(request):
+    return text("42")
+
+if __name__ == '__main__':
+    app.run(host="0.0.0.0", port=8000)
diff --git a/sanic/router.py b/sanic/router.py
index 081b5da6..a1f47230 100644
--- a/sanic/router.py
+++ b/sanic/router.py
@@ -55,8 +55,9 @@ class Router:
         self.routes_static = {}
         self.routes_dynamic = defaultdict(list)
         self.routes_always_check = []
+        self.hosts = None
 
-    def add(self, uri, methods, handler):
+    def add(self, uri, methods, handler, host=None):
         """
         Adds a handler to the route list
         :param uri: Path to match
@@ -66,6 +67,17 @@ class Router:
         When executed, it should provide a response object.
         :return: Nothing
         """
+
+        if host is not None:
+            # we want to track if there are any
+            # vhosts on the Router instance so that we can
+            # default to the behavior without vhosts
+            if self.hosts is None:
+                self.hosts = set(host)
+            else:
+                self.hosts.add(host)
+            uri = host + uri
+
         if uri in self.routes_all:
             raise RouteExists("Route already registered: {}".format(uri))
 
@@ -113,7 +125,9 @@ class Router:
         else:
             self.routes_static[uri] = route
 
-    def remove(self, uri, clean_cache=True):
+    def remove(self, uri, clean_cache=True, host=None):
+        if host is not None:
+            uri = host + uri
         try:
             route = self.routes_all.pop(uri)
         except KeyError:
@@ -137,10 +151,14 @@ class Router:
         :param request: Request object
         :return: handler, arguments, keyword arguments
         """
-        return self._get(request.url, request.method)
+        if self.hosts is None:
+            return self._get(request.url, request.method, '')
+        else:
+            return self._get(request.url, request.method,
+                             request.headers.get("Host", ''))
 
     @lru_cache(maxsize=Config.ROUTER_CACHE_SIZE)
-    def _get(self, url, method):
+    def _get(self, url, method, host=None):
         """
         Gets a request handler based on the URL of the request, or raises an
         error.  Internal method for caching.
@@ -148,6 +166,7 @@ class Router:
         :param method: Request method
         :return: handler, arguments, keyword arguments
         """
+        url = host + url
         # Check against known static routes
         route = self.routes_static.get(url)
         if route:
diff --git a/sanic/sanic.py b/sanic/sanic.py
index 3dab3e47..6926050c 100644
--- a/sanic/sanic.py
+++ b/sanic/sanic.py
@@ -51,7 +51,7 @@ class Sanic:
     # -------------------------------------------------------------------- #
 
     # Decorator
-    def route(self, uri, methods=None):
+    def route(self, uri, methods=None, host=None):
         """
         Decorates a function to be registered as a route
         :param uri: path of the URL
@@ -65,12 +65,13 @@ class Sanic:
             uri = '/' + uri
 
         def response(handler):
-            self.router.add(uri=uri, methods=methods, handler=handler)
+            self.router.add(uri=uri, methods=methods, handler=handler,
+                            host=host)
             return handler
 
         return response
 
-    def add_route(self, handler, uri, methods=None):
+    def add_route(self, handler, uri, methods=None, host=None):
         """
         A helper method to register class instance or
         functions as a handler to the application url
@@ -80,11 +81,11 @@ class Sanic:
         :param methods: list or tuple of methods allowed
         :return: function or class instance
         """
-        self.route(uri=uri, methods=methods)(handler)
+        self.route(uri=uri, methods=methods, host=host)(handler)
         return handler
 
-    def remove_route(self, uri, clean_cache=True):
-        self.router.remove(uri, clean_cache)
+    def remove_route(self, uri, clean_cache=True, host=None):
+        self.router.remove(uri, clean_cache, host)
 
     # Decorator
     def exception(self, *exceptions):
diff --git a/tests/test_vhosts.py b/tests/test_vhosts.py
new file mode 100644
index 00000000..7bbbb813
--- /dev/null
+++ b/tests/test_vhosts.py
@@ -0,0 +1,23 @@
+from sanic import Sanic
+from sanic.response import json, text
+from sanic.utils import sanic_endpoint_test
+
+
+def test_vhosts():
+    app = Sanic('test_text')
+
+    @app.route('/', host="example.com")
+    async def handler(request):
+        return text("You're at example.com!")
+
+    @app.route('/', host="subdomain.example.com")
+    async def handler(request):
+        return text("You're at subdomain.example.com!")
+
+    headers = {"Host": "example.com"}
+    request, response = sanic_endpoint_test(app, headers=headers)
+    assert response.text == "You're at example.com!"
+
+    headers = {"Host": "subdomain.example.com"}
+    request, response = sanic_endpoint_test(app, headers=headers)
+    assert response.text == "You're at subdomain.example.com!"