diff --git a/sanic/sanic.py b/sanic/sanic.py
index cc362d2d..f891a761 100644
--- a/sanic/sanic.py
+++ b/sanic/sanic.py
@@ -390,6 +390,11 @@ class Sanic:
         """
         server_settings['reuse_port'] = True
 
+        if server_settings['loop'] is not None:
+            log.warn("Passing the loop is not supported with multiple"
+                     " workers. The loop paramater has been set to None.")
+            server_settings['loop'] = None
+
         # Create a stop event to be triggered by a signal
         if stop_event is None:
             stop_event = Event()