diff --git a/sanic/base.py b/sanic/base.py
index 51706149..368288c4 100644
--- a/sanic/base.py
+++ b/sanic/base.py
@@ -8,38 +8,19 @@ from sanic.mixins.routes import RouteMixin
 from sanic.mixins.signals import SignalMixin
 
 
-class Base(type):
-    def __new__(cls, name, bases, attrs):
-        init = attrs.get("__init__")
-
-        def __init__(self, *args, **kwargs):
-            nonlocal init
-            nonlocal name
-
-            bases = [
-                b for base in type(self).__bases__ for b in base.__bases__
-            ]
-
-            for base in bases:
-                base.__init__(self, *args, **kwargs)
-
-            if init:
-                init(self, *args, **kwargs)
-
-        attrs["__init__"] = __init__
-        return type.__new__(cls, name, bases, attrs)
-
-
 class BaseSanic(
     RouteMixin,
     MiddlewareMixin,
     ListenerMixin,
     ExceptionMixin,
     SignalMixin,
-    metaclass=Base,
 ):
     __fake_slots__: Tuple[str, ...]
 
+    def __init__(self, *args, **kwargs) -> None:
+        for base in BaseSanic.__bases__:
+            base.__init__(self, *args, **kwargs)  # type: ignore
+
     def __str__(self) -> str:
         return f"<{self.__class__.__name__} {self.name}>"
 
diff --git a/sanic/blueprints.py b/sanic/blueprints.py
index f8b0323c..85b60ddc 100644
--- a/sanic/blueprints.py
+++ b/sanic/blueprints.py
@@ -73,6 +73,7 @@ class Blueprint(BaseSanic):
         version: Optional[int] = None,
         strict_slashes: Optional[bool] = None,
     ):
+        super().__init__()
 
         self._apps: Set[Sanic] = set()
         self.ctx = SimpleNamespace()
diff --git a/tests/test_app.py b/tests/test_app.py
index bfe7900c..f096496a 100644
--- a/tests/test_app.py
+++ b/tests/test_app.py
@@ -405,3 +405,10 @@ def test_app_set_context(app):
 
     retrieved = Sanic.get_app(app.name)
     assert retrieved.ctx.foo == 1
+
+
+def test_subclass_initialisation():
+    class CustomSanic(Sanic):
+        pass
+
+    CustomSanic("test_subclass_initialisation")