diff --git a/examples/vhosts.py b/examples/vhosts.py
index 40dc7ba5..810dc513 100644
--- a/examples/vhosts.py
+++ b/examples/vhosts.py
@@ -11,9 +11,16 @@ from sanic.blueprints import Blueprint
 app = Sanic()
 bp = Blueprint("bp", host="bp.example.com")
 
+@app.route('/', host=["example.com",
+                      "somethingelse.com",
+                      "therestofyourdomains.com"])
+async def hello(request):
+    return text("Some defaults")
+
 @app.route('/', host="example.com")
 async def hello(request):
     return text("Answer")
+
 @app.route('/', host="sub.example.com")
 async def hello(request):
     return text("42")
diff --git a/sanic/router.py b/sanic/router.py
index a8ad7c13..e817be9c 100644
--- a/sanic/router.py
+++ b/sanic/router.py
@@ -76,8 +76,15 @@ class Router:
             if self.hosts is None:
                 self.hosts = set(host)
             else:
+                if isinstance(host, list):
+                    host = set(host)
                 self.hosts.add(host)
-            uri = host + uri
+            if isinstance(host, str):
+                uri = host + uri
+            else:
+                for h in host:
+                    self.add(uri, methods, handler, h)
+                return
 
         # Dict for faster lookups of if method allowed
         if methods:
diff --git a/tests/test_vhosts.py b/tests/test_vhosts.py
index 7bbbb813..660ebb5f 100644
--- a/tests/test_vhosts.py
+++ b/tests/test_vhosts.py
@@ -4,7 +4,7 @@ from sanic.utils import sanic_endpoint_test
 
 
 def test_vhosts():
-    app = Sanic('test_text')
+    app = Sanic('test_vhosts')
 
     @app.route('/', host="example.com")
     async def handler(request):
@@ -21,3 +21,19 @@ def test_vhosts():
     headers = {"Host": "subdomain.example.com"}
     request, response = sanic_endpoint_test(app, headers=headers)
     assert response.text == "You're at subdomain.example.com!"
+
+
+def test_vhosts_with_list():
+    app = Sanic('test_vhosts')
+
+    @app.route('/', host=["hello.com", "world.com"])
+    async def handler(request):
+        return text("Hello, world!")
+
+    headers = {"Host": "hello.com"}
+    request, response = sanic_endpoint_test(app, headers=headers)
+    assert response.text == "Hello, world!"
+
+    headers = {"Host": "world.com"}
+    request, response = sanic_endpoint_test(app, headers=headers)
+    assert response.text == "Hello, world!"