diff --git a/sanic/constants.py b/sanic/constants.py
index cb2e8ffa..80f1d2a9 100644
--- a/sanic/constants.py
+++ b/sanic/constants.py
@@ -1,2 +1,28 @@
-HTTP_METHODS = ("GET", "POST", "PUT", "HEAD", "OPTIONS", "PATCH", "DELETE")
+from enum import Enum, auto
+
+
+class HTTPMethod(str, Enum):
+    def _generate_next_value_(name, start, count, last_values):
+        return name.upper()
+
+    def __eq__(self, value: object) -> bool:
+        value = str(value).upper()
+        return super().__eq__(value)
+
+    def __hash__(self) -> int:
+        return hash(self.value)
+
+    def __str__(self) -> str:
+        return self.value
+
+    GET = auto()
+    POST = auto()
+    PUT = auto()
+    HEAD = auto()
+    OPTIONS = auto()
+    PATCH = auto()
+    DELETE = auto()
+
+
+HTTP_METHODS = tuple(HTTPMethod.__members__.values())
 DEFAULT_HTTP_CONTENT_TYPE = "application/octet-stream"
diff --git a/sanic/router.py b/sanic/router.py
index e3343037..0973a3fa 100644
--- a/sanic/router.py
+++ b/sanic/router.py
@@ -109,7 +109,7 @@ class Router(BaseRouter):
         params = dict(
             path=uri,
             handler=handler,
-            methods=methods,
+            methods=frozenset(map(str, methods)) if methods else None,
             name=name,
             strict=strict_slashes,
             unquote=unquote,
diff --git a/tests/test_constants.py b/tests/test_constants.py
new file mode 100644
index 00000000..7ce6e4d7
--- /dev/null
+++ b/tests/test_constants.py
@@ -0,0 +1,28 @@
+from crypt import methods
+
+from sanic import text
+from sanic.constants import HTTP_METHODS, HTTPMethod
+
+
+def test_string_compat():
+    assert "GET" == HTTPMethod.GET
+    assert "GET" in HTTP_METHODS
+    assert "get" == HTTPMethod.GET
+    assert "get" in HTTP_METHODS
+
+    assert HTTPMethod.GET.lower() == "get"
+    assert HTTPMethod.GET.upper() == "GET"
+
+
+def test_use_in_routes(app):
+    @app.route("/", methods=[HTTPMethod.GET, HTTPMethod.POST])
+    def handler(_):
+        return text("It works")
+
+    _, response = app.test_client.get("/")
+    assert response.status == 200
+    assert response.text == "It works"
+
+    _, response = app.test_client.post("/")
+    assert response.status == 200
+    assert response.text == "It works"